Release properties of titanium-based nano-silver coating

doi:10.3969/j.issn.2095-4344.2014.39.018

Abstract

Abstract:

BACKGROUND: Surface modification of orthopedic implants can reduce or prevent bacterial adhersion. Bacteriostatic and bactericidal ingredients released from special coating of metal surfaces prevent orthopedic surgery infection.
OBJECTIVE: To prepare hydroxyapatite/nano-silver composite coating on the surface of medical titanium based on different preparation parameters and to observe the release properties of silver ions on the composite material surface in the simulated body fluid.
METHODS: Using pulse electrochemical methods, hydroxyapatite and nano-silver were deposited in the solution containing silver, calcium and phosphate ions. Scanning electron microscopy, X-ray diffraction and energy dispersive spectroscopy were used to characterize its morphology and composition. The composite titanium materials containing 0.5, 1 mmol/L silver were immersed in the simulated body fluid, and Ag+ concentration was detected by atomic absorption spectrometry at the different time points.
RESULTS AND CONCLUSION: Nanoparticles were uniformly distributed in the coating which was interwoven with the nano needle-like hydroxypatite and dot-like silver particles. After high temperature processing, the coating became denser, and hydroxypatite became more crystal and silver particles exhibited no agglomeration. In the simulated body fluid, Ag+ release was maximal at 1-7 days and became stable at 7-30 days which maintained an effective antimicrobial concentration. The material containing 0.5 mmol/L Ag⁺ showed a lower amount of Ag⁺ released than cytotoxic concentration at 30 days, but the material containing 1 mmol/L Ag⁺ could release the total of Ag⁺ close to the critical value of cell toxicity at 30 days. Above all, the material containing 0.5 mmol/L Ag⁺ is more secure in the clinical application.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: hydroxyapatites, metal nanoparticles, titanium

CLC Number:

R318

Xian Ai-ming, Zhang Xiao-gang, Cao Li, Wang Jia-ming, Peng Li-bin, Hu Yang. Release properties of titanium-based nano-silver coating[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(39): 6335-6341.

Figures/Tables 6

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